The opposition in Niger has called for a boycott, alleging fraud, and the BBC's Ishaq Khalid says he has not seen many voters in the capital, Niamey.
President Muhamadou Issoufou is expected to win a second term in the vote against former prime minister and parliamentary speaker Hama Amadou.
Mr Amadou was jailed in November on baby-trafficking charges, which he denies. He was flown to Paris last week for medical treatment.
His medical condition is unclear, but his health reportedly deteriorated in prison.
One of the world's poorest countries, Niger faces a growing jihadist threat and was attacked by militants from al-Qaeda and Boko Haram on Thursday.
In February's first round, Mr Issoufou got 48% of the vote while Mr Amadou came second with 17%.
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